Background:Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), is a widely used non-steroidal anti-inflammatory drug (NSAID) that is frequently associated with gastrointestinal disorders like gastrointestinal ulceration or bleeding. In the United States, approximately 30 million people have asthma or allergic rhinitis, and over 4 million people have asthma.1

Objective:To evaluate the efficacy of ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), in reducing asthma symptoms in children and adults with severe asthma exacerbations. Methods: We evaluated the efficacy of ibuprofen (IBU) in reducing asthma symptoms in children and adults with severe asthma, and compared it with placebo.

Methods:We performed a systematic search in Medline and ScienceDirect database, and a literature search was performed. We used Cochrane Central Register of Controlled Trials (CENTRAL), Medical Abstracts of Health Care Allied (MACE) and British Association for Pharmacoepidemiology (BAHP) databases. We also searched for reference to published English-language English-language English-language medical literature. The primary outcome was the proportion of children and adults with asthma or allergic rhinitis that experienced asthma symptoms.

Results:We identified 17 publications that met the inclusion criteria, including 14 randomized controlled trials and 17 placebo-controlled trials. We included two double-blind, placebo-controlled studies, and found no difference in efficacy between children and adults with asthma and allergic rhinitis. There was no significant difference in efficacy between children and adults with asthma. There were 17 children with severe asthma who met inclusion criteria and were randomized to ibuprofen (placebo) or placebo in this study. There was no difference in efficacy between children and adults with asthma and allergic rhinitis, and there was no difference between children and adults with asthma and allergic rhinitis in other studies. There was no difference in efficacy between ibuprofen and placebo in children with asthma and allergic rhinitis, and there was no significant difference in efficacy between ibuprofen and placebo in children with asthma. In conclusion, ibuprofen, a non-steroidal anti-inflammatory drug, may be a useful treatment for severe asthma in children and adults. Ibuprofen may be useful for severe asthma in children and adults, and may be effective for treating moderate asthma.

Conclusions:Our findings suggest that ibuprofen may be an effective treatment for severe asthma in children and adults with asthma. Ibuprofen may be a suitable treatment for children with severe asthma.

Table 1 Ibuprofen and a Non-steroidal Anti-inflammatory Drug

Table 1 Study Number

Summary

Findings of the evidence [1,2,3,4,5,6]

No significant differences in the effectiveness of ibuprofen in reducing asthma symptoms in children and adults with asthma and allergic rhinitis were found between children and adults. There were no significant differences in efficacy between children and adults with asthma and allergic rhinitis. Ibuprofen may be a useful treatment for severe asthma in children and adults with asthma. Ibuprofen may be useful for severe asthma in children and adults with allergic rhinitis.

Received:January 4, 2005;Accepted:February 12, 2006;Published:March 24, 2006

Citation:Diamarti M, Ghaemi M, et al. (2005) Comparison of the effects of ibuprofen and placebo on children and adults with severe asthma. Journal of the National Institutes of Health/British Medical Association, 1:Approval date:August 17, 2005

Keywords: Asthma, asthma, allergic rhinitis, NSAID, NSAID, NSAID-D, NSAID-S

Abbreviations:CNS: Central Nervous System, FDA: Food and Drug Administration, NSAID: Nonsteroidal Anti-inflammatory Drug, PBM: Pediatric Multicenter Study, PMR: Primary Prevention Research, VHA: Vascular Risk Factors Study, NSAID: Nonsteroidal Anti-inflammatory Drug, PBM: Pediatric Multicenter Study, VHA: Vascular Risk Factors Study.

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IBURAX 800MG TABLET

Product NameActive IngredientAs hydroxyzine hydroxyManufacturerSrinagarProduct Description

IBURAX 800MG TABLET is used to relieve the symptoms of colds and flu. It relieves only the inflammation caused by colds and flu. However, this medicine may work against other medicines as well.

How to take it

Nurofen Tablet – Take one tablet by mouth, with or without food, as directed by your doctor. Do not exceed the recommended dose. Swallow the tablets whole with water. You should take this medicine for as long as it is prescribed.

Inhaled corticosteroids may include:

• Steroids such as ibuprofen and diclofenac
• Tussventions involving muscle spasms or cramps
• Pain or discomfort from stomach or intestinal ulcers
• Pain, swelling or irritation in muscles or joints
• Injuries to the lining of the stomach or intestines
• If you are pregnant or breastfeeding

Follow the directions given to you by your doctor, particularly after you have drunk plenty of alcohol.

If you forget to take the dose, take the missed dose as soon as the next time you remember. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take two doses at the same time.

When to take it

The usual dose is one tablet twice a day. However, your doctor may increase or decrease your dose depending on your age, body weight, and disease condition.

Overdose

Seek emergency medical attention if you have experienced an overdose of this medicine. Symptoms may include extreme nausea, vomiting, loss of appetite, stomach pain, or yellowing of the skin or whites of the eyes or other organs. Do not consume this medicine without consulting your doctor.

Do not stop taking the medicine without first consulting your doctor.

Side effects

The most common side effects of this medicine include:

• Nausea
• Vomiting
• Fever
• Headache

If you experience any severe or persistent side effects, contact your doctor immediately.

Do not discontinue using this medicine without consulting your doctor.

Cautions

If you are allergic to hydroxyzine hydroxy or any other ingredients in this medicine, stop taking this medicine and contact your doctor immediately. Other than that, you must not take this medicine if you have severe heart disease, slow heart rate, low blood pressure, kidney or liver problems, are a pregnant or breast feeding child, or if you are under 60 years of age.

Do not take this medicine if you are pregnant or breast-feeding.

Storage

Store this medicine at room temperature, and keep it out of the reach of children.

References

• Srinagar(R)--Rajdocel Limited, India. Sourcing Ibuprofen 800mg Tablet from India, US, Canada & UK.. Available at:.

• Productos SinRagar Rajdocel India, US, Canada and UK.

Ibuprofen tablets belong to a group of medicines called nonsteroidal anti-inflammatory drugs (NSAIDs). It is used to relieve pain, inflammation, and fever.

This medicine is used to reduce fever and relieve pain in infants, children, and adults with conditions such as:

• Infant respiratory infection
• Inflammation of the sinuses (sinusitis)
• An underdeveloped immune system (e.g., red blood cells, white blood cells, and plasma)
• Treatment of headache and other pain
• Treatment of minor aches and fever with over-the-counter pain relievers, such as ibuprofen

It may also be used to reduce pain after surgery or dental procedures.

Ibuprofen tablets are available as an over-the-counter drug in different strengths, as well as as in generic, and brand-name versions.

Take this medicine by mouth with a full glass of water, with or without food, or with a full meal.

The medicine should be taken with or without food, as it is best taken on an empty stomach.

The amount of medicine in a single tablet can be adjusted by the doctor, depending on the patient's condition and response to the medicine.

The usual dose of ibuprofen tablets for children is 200-300mg per day, taken at least 1 hour before or 2 hours after meals.

Ibuprofen tablets are for oral use only. Consult your doctor or pharmacist for more details.

Ibuprofen tablets can be taken with or without food, although a high-fat meal may delay the effects.

Do not take ibuprofen tablets if you are allergic to ibuprofen or other non-steroidal anti-inflammatory drugs (NSAIDs), aspirin, or other medicines for pain or fever. Do not take ibuprofen tablets if you are pregnant, planning to become pregnant, or breastfeeding.

Inform your doctor if you have allergies to medicines, foods, or other substances to avoid possible side effects.

Before taking this medicine, inform your doctor if you have a history of stomach problems, heart disease, liver or kidney disease, stomach bleeding, or other ulcers, or other medical conditions that could make them worse.

Tell your doctor if you are pregnant or breastfeeding.

This medicine is excreted in the body, passes through the body, or enters the breast milk. Do not use in children under 12 years old.

It may also have other uses, such as if it relieves pain or prevents inflammation.

Inform your doctor if you are planning to have a child.The drug is not addictive.The drug's effects may last for up to 12 hours. Consult your doctor for more details.This medicine is not addictive.Ibuprofen tablets are available in packs of 4 (100 mg), 8 (200 mg), and 12 (400 mg) tablets, which are taken 1-2 times a day. It is important to follow the directions on the label or the medicine packet for safety and effectiveness. Do not chew, crush, or break the tablets.

Store at room temperature in a dry place, away from direct sunlight and heat.

Store the medicine at room temperature, away from moisture and heat.

Keep all your healthcare appointments. Your doctor will check your liver and kidney function.

The medicine works best when the packaging is kept out of direct sunlight.

The medicine contains the same active ingredient, ibuprofen. Do not use it if you are suffering from pain due to inflammation of the joints or due to a fever.

The medicine is excreted in the body, passes through the body, or enters the breast milk.

If your doctor approves it, you should take it 1-2 hours before or 2 hours after meals. Do not take it more often than once a day.

Store at room temperature, away from direct sunlight and heat.

The medicine contains gelatin.

Keep the medicine out of reach of children. Do not use it in the eyes, nose, or mouth.

Store at room temperature, away from moisture and heat.

For the full prescribing information for all patients aged 65 years or older on Aspirin, please visit the prescribing information pages at the bottom of this leaflet. Please do not give this leaflet to people aged 65 years or older.

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7. What is Aspirin used for?8. What are the possible side effects of Aspirin?9.

10. How to store Ibuprofen?10. What is Aspirin for?11. What is the use of Aspirin for pain relief?12. What are the possible side effects of Ibuprofen?13. How to store Ibuprofen

14. What is Aspirin used for?14. How should Aspirin be used?14. What are the possible side effects of Aspirin?14.

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